KLF5 and esophageal adenocarcinoma: In esophageal adenocarcinoma, KLF5 was identified as one of the four esophageal adenocarcinoma-specific master regulator transcription factors (MRTF) that control, among others, de novo synthesis of fatty acids, phospholipids, and sphingolipids through peroxisome proliferator-activated receptor gamma (PPARγ) [43].