We recently found that VDAC1 is over-expressed not only in cancer [22,35,36,37], but also in several diseases such as Alzheimer’s disease (AD) [38,39,40], type 2 diabetes (T2D) [41,42,43], and autoimmune diseases such as lupus [44] and colitis [45]. Here, VDAC1 is linked to systemic lupus erythematosus.