As overexpressed VDAC1 triggers cell death via its oligomerization [46,47,48], we developed new molecules, e.g., VBIT-4 and VBIT-12, that prevent this oligomerization and subsequent apoptosis [49], and inhibit VDAC1 conductance, as was also validated in T2D [43], lupus [44], and colitis [45] mouse models. Here, VDAC1 is linked to colitis.