Collection and analyses of blood glucose through 8 h of fasting (0, 2, 4, 6, 8) in 4–6 weeks old WT or Phkb−/− mice (WT = 11, Phkb−/− = 9) showed that Phkb−/− mice maintained reduced blood glucose levels compared to WT mice during fasting with significant differences at 6 and 8 h; severe hypoglycemia, however, did not develop (Figure 2A). The gene discussed is PHKB; the disease is Hypoglycemia.