Interestingly, Lebrikizumab, a mouse antibody that interacts with IL-13 and is effective in treatment of AD itch, reduces neuronal gene transcription in human sensory neurons, including IL-13Rα2, suggestive that IL-13Rα2 is a downstream target and contributes to the relief of AD itch [144]. The gene discussed is IL13; the disease is Alzheimer disease.