Although cheek injection of CXCL10 failed to directly cause scratching-like behaviors within a specific dose range [20], CXCL10 has been shown to drive acute itch in a model of allergic contact dermatitis via C-X-C chemokine receptor 3 (CXCR3) signaling in sensory neurons [190]. This evidence concerns the gene CXCL10 and allergic contact dermatitis.