There are many signaling pathways, mediators, and downstream signaling proteins reported in angiogenesis-induced cancer: platelet-derived growth factor (PDGF), VEGF, fibroblast growth factors (FGF), hepatocyte growth factor (HGF), TKs, PI3K, MAPK, mTOR, Ras, and Raf [71,141,142,143,144]. This evidence concerns the gene MTOR and cancer.