SMURF1 and osteoporosis: The study also found that miR-195-5p achieved BMP-2/Smad/Akt/RUNX2 axis activation by targeting and suppressing Smurf1 to accelerate osteogenic differentiation of MC3T3-E1 in vitro and relieve osteoporosis progression in an ovariectomized (OVX) mouse model [57].