After integrating single-cell data from different BC subtypes, 73,866 cells from 15 samples were obtained, and eight major cell types including epithelial cells (EPCAM+), proliferating cells (MKI67+), T cells (CD3D+), myeloid cells (CD68+), B cells (MS4A1+), plasma cells (JCHAIN+), endothelial cells (PECAM1+) and mesenchymal cells (PDGFRB+) were identified by cell markers (Figure 2A,B). The gene discussed is JCHAIN; the disease is breast cancer.