Based on our subtype-specific prognostic models, HPGD, CDC42, and PGK1 are the risk factors of TNBC, ACTR6, SULT1A2 and C2orf76 are the risk factors of HER2+ BC, while ATP6AP1, RNF139, BASP1, ESR1 and TSKU are the risk factors of luminal BC. The gene discussed is ESR1; the disease is breast cancer.