AKT1 and brain neoplasm: In another study, a zebrafish model of brain tumours was developed using a Gal4/UAS system to induce the somatic expression of oncogenes, such as HRASG12V or YAPS5A, KRASG12V, AKT, EGFRvIII and BRAFV600E under the control of zic4 enhancer, which activates MAPK and PI3K signalling pathways.