It created the loss-of-function alleles of nf1a and nf1b, NF1 orthologues in zebrafish, which accelerated the tumour onset and increased the penetrance of high-grade gliomas and malignant peripheral nerve sheath tumours (MPNSTs), indicating the tumour suppressive role of nf1 in zebrafish [110]. The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.