A recent study by Umans R. A. et al. demonstrated the use of zebrafish PDX (zPDX) xenografts to model perivascular glioma invasion through the orthotopic transplantation of tumour cells into transgenic Tg(fli1:GFP) casper embryos and validated the pharmacological disruption of glioma cell-vascular interactions by inhibiting the Wnt signalling pathways [228]. The gene discussed is FLI1; the disease is central nervous system cancer.