The results of this study suggest that aerobic exercise may enhance the autophagy–lysosomal pathway through the activation of the AdipoR1/AMPK/TFEB signaling pathway in APP/PS1 mice and alleviate autophagy abnormalities, thereby reducing Aβ deposition, inhibiting neural apoptosis and dendritic spine loss, and alleviating cognitive dysfunction in AD (Figure 11). Here, TFEB is linked to Alzheimer disease.