APPL1 and Alzheimer disease: In order to further study the molecular mechanism by which the AdipoR1 signaling pathway participated in aerobic exercise’s alleviation of AD-like lesions, our group detected the expression and phosphorylation of the AMPK protein, a signaling molecule downstream of AdipoR1, and the mRNA expression levels of the signaling molecules between AdipoR1 and AMPK in mouse brain tissue: adaptor protein containing pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif (APPL1) and liver kinase B1 (LKB1).