CTSD and Alzheimer disease: Previous studies have also shown that exercise can enhance the expression of lysosomal-function-related proteins such as cathepsin D/L and LAMP1 in AD brain tissue by activating the AMPK/TFEB signaling pathway, improve autophagic degradation, and promote autophagy, thereby promoting Aβ degradation, inhibiting apoptosis, and reducing Aβ plaque [4,6,50].