At the same time, the expression levels of transcription factor EB (TFEB) and nuclear translocation in brain cells, the expression levels of lysosomal function-related proteins and genes downstream of TFEB, and the expression levels of the phospholipase C (PLC)/downstream regulatory element antagonist modulator (DREAM/Kcnip3)/E3 ligase Midline-1 (Mid1)/protein phosphatase 2A (PP2A) genes in the upstream signaling pathway for TFEB were detected to determine the possible role of the APN–AdipoR1 signaling pathway in exercise’s enhancement of AD lysosomal function. Here, HSPG2 is linked to Alzheimer disease.