TGFB1 and open-angle glaucoma: In addition to the well-known fact that TGF-β2 is involved in the pathogenesis of glaucomatous TM [16], the bioinformatic prioritization and functional annotation of candidate genes for POAG in genome-wide association studies (GWASs) identified that RA nuclear receptor signaling and TGF-β blood vessel development were the most significant pathways related to ECM metabolism [31].