Circular RNAs’ role in periodontal disease has also been studied by other authors, with the main findings being the overexpression of hsa_circ_0003948 with a protective effect in chronic periodontitis via miR-144-3p/NR2F2/PTEN signaling regulation [63], and a promising biomarker for periodontitis treatment, circ_0085289, alleviated PDLC injury induced by LPS stimulation by modulating the let-7f-5p/SOCS6 axis [64]. This evidence concerns the gene PTEN and periodontitis.