That study used controlled experimental in vivo RV infection in healthy controls and patients with asthma, as well as in vitro models of house dust mite (HDM) exposure and RV/SARS-CoV-2 coinfection, in primary airway epithelial cells from both groups and found that RV infection in patients with asthma led to the overactivation of RIG-I inflammasomes, which diminished RIG-I accessibility for type I and III IFN responses in airway epithelial cells, leading to their functional impairment, prolonged viral clearance, and unresolved inflammation in vivo and in vitro. This evidence concerns the gene RIGI and asthma.