IFNA1 and asthma: That study used controlled experimental in vivo RV infection in healthy controls and patients with asthma, as well as in vitro models of house dust mite (HDM) exposure and RV/SARS-CoV-2 coinfection, in primary airway epithelial cells from both groups and found that RV infection in patients with asthma led to the overactivation of RIG-I inflammasomes, which diminished RIG-I accessibility for type I and III IFN responses in airway epithelial cells, leading to their functional impairment, prolonged viral clearance, and unresolved inflammation in vivo and in vitro.