According to DAVID Bioinformatics Resources, the proteins found more abundant in relapsed HL in both the exploratory and the validation phases of our study share the following four biological processes: “innate immune response” (GO:0045087; including CLU and C4BPA), “fibrinolysis” (GO:0042730; including F2 and FGG), “blood coagulation” (GO:0007596; including F2 and FGG), and “positive regulation of neurofibrillary tangle assembly” (GO:1902998; including CLU and C4BPA) (Supplementary File DAVID_raw data, sheets 1 and 2). The gene discussed is CLU; the disease is Hodgkins lymphoma.