The diagnosis of overt myeloma is based on the presence of at least 10% of clonal bone marrow plasma cell (BMPC) and serum M-protein or urinary monoclonal component, together with the presence of myeloma-related organ dysfunction, including increased calcium level, renal dysfunction, anaemia, and bone lesions (CRAB criteria), or the recently defined as SLIM CRAB criteria, that include clonal BMPC infiltration >60%, involved/uninvolved free light chain (FLC) ratio >100 (involved FLC level must be >100 mg/L) and >1 focal lesion (FL) on Magnetic Resonance Imaging (MRI) larger than 5 mm [4,5]. The gene discussed is MYOM2; the disease is plasma cell myeloma.