SFRP5 and obesity due to melanocortin 4 receptor deficiency: On the subject of SFRP5 mRNA expression in VAT, we found a positive correlation with the proinflammatory cytokines IL-1β, IL-17 and PAI-1 levels, whose increase has been linked to obesity and NAFLD [78,89,90], and with IL-13, a cytokine with an anti-inflammatory role that used to be increased in obesity [91], which presents beneficial effects in hepatic diseases [92], as we previously hypothesized that SFRP5 does.