Based on the previous results and given that NAFLD development is susceptible to adipokines released from adipose tissue, the synthesis location of SFRP5, the aim of the present work was to evaluate the role of the SFRP5/WNT5A/PPARγ pathway in SAT and VAT and its link with NAFLD pathogenesis in a cohort of NW and MO women, with the latter subclassified according to their hepatic histopathology. Here, SFRP5 is linked to metabolic dysfunction-associated steatotic liver disease.