WNT5A and obesity due to melanocortin 4 receptor deficiency: Moreover, it is important to note that SAT and VAT depots presented different patterns of expansion during obesity [54], and given that the activation of WNT signaling by high-fat diet stimulates hypertrophy and overproliferation of adipocytes in SAT [55], we hypothesize that a very restrictive diet could induce the opposite effect inactivating WNT5A pathway.