To our knowledge, we are the first to investigate the SFRP5/WNT5A pathway in the adipose tissue regarding NAFLD presence in humans, and our results suggested that patients with NAFLD presented enhanced expression of SFRP5 in adipose tissues, specifically in the SAT of NASH patients and in the VAT of subjects with NASH or mild SS. Here, SFRP5 is linked to metabolic dysfunction-associated steatohepatitis.