Similarly, in our previous study, we evaluated SFRP5 serum levels and hepatic SFRP5, WNT5A and c-Jun N-terminal kinase (JNK), an intermediate of the noncanonical WNT5A pathway, mRNA expression in patients with morbid obesity (MO) and NAFLD. The gene discussed is SFRP5; the disease is metabolic dysfunction-associated steatotic liver disease.