ANXA1 and neoplasm: Importantly, the key network nodes (high betweenness) for the quiescent subpopulation are represented by Annexin A1, a protein involved in metastasis, suppression of inflammation and of the immune response [67,68,69,70,71], by the antioxidant enzyme catalase, involved in the protection from reactive oxygen species and in chemotherapy resistance [72], and by Methaderin, a protein involved in multiple steps of tumor progression and metastasis [73].