Our current research results show that α-boswellic acid can effectively improve the erythema, abrasion, and desquamation, as well as repair the dysfunctional skin barrier, reduce inflammation, reduce mast cell infiltration, reduce MAP kinase expression, and inhibit the NF-κB pathway in AD model mouse skin and TNF-α/IFN-γ-stimulated HaCaT cells. Here, TNF is linked to Alzheimer disease.