CRHR2 variants have also been reported in patients with bipolar disorder (rs8192492-risk allele-A) [22], PTSD (rs2267715-risk allele-A) [23], and T2D (rs917195 T2D-risk allele-C) [24]; and certain haplotypes have been associated with suicidal risk in bipolar patients [57]. This evidence concerns the gene CRHR2 and type 2 diabetes mellitus.