CRHR2 and major depressive disorder: Interestingly, the variants linked to or in LD (i.e., association) with MDD had generally higher statistical significance level than the variants linked to or in LD (i.e., association) with T2D, despite the fact that the families were primarily ascertained for T2D, indicating that CRHR2 variants may confer a risk for MDD more strongly than for T2D.