Nevertheless, the strength of this feasibility study lies in the results showing that IL-23 and RANKL may help to elucidate the pathogenesis during the conversion from peri-implant health to peri-implantitis; and the potential use of BAFF/BLyS for the early diagnosis of peri-implantitis. This evidence concerns the gene TNFSF11 and Peri-Implantitis.