As chronic inflammatory activation of microglia is correlated with several neurodegenerative diseases, the endocannabinoid (eCB) system cannabinoid 2 receptor (CB2R) signaling shifts the balance of neuroprotective genes, and homeostatic genes may acquire therapeutic functionality in microglia for neuroinflammation involved in ASD [79]. This evidence concerns the gene CNR2 and neurodegenerative disease.