We identified a more holistic mechanism of apoptosis and found that heat-killed B. bifidum MG731, L. reuteri MG5346, and L. rhamnosus MG5200 regulated the expression of p-Akt, p53, Bax, and Bak in xenograft-derived tumor tissues (Figure 4 and Figure 6). Here, BAK1 is linked to neoplasm.