PICALM and early-onset autosomal dominant Alzheimer disease: In a large GWAS from 2013, Lambert et al. found that several additional common variants were associated with a risk of Alzheimer’s disease, including complement C3b/C4b receptor 1 gene (CR1), bridging integrator 1 gene (BIN1), clusterin gene (CLU), phosphatidylinositol-binding clathrin assembly protein gene (PICALM), and Ras and Rab interactor 3 gene (RIN3) [141].