In 2011, Hollingworth et al. discovered several new loci associated with risk of Alzheimer’s disease, including ATP-binding cassette transporter A7 gene (ABCA7), CD2-associated protein gene (CD2AP), ephrin type-A receptor 1 gene (EPHA1), membrane-spanning 4A gene (MS4A), and sialic acid binding Ig-like lectin 3 (CD33) [147]. This evidence concerns the gene ABCA7 and early-onset autosomal dominant Alzheimer disease.