Although the nadir of vision loss is severe with MOGAD-ON, the recovery is typically better than with AQP4-IgG ON, and, in general, MOGAD-associated demyelination has been suggested to have a more favorable prognosis compared with AQP4-seropositive NMOSD, featuring a lower EDSS and reduced risk of visual and motor disability. This evidence concerns the gene AQP4 and Peripheral demyelination.