As already evoked in the introduction, its off-target binding to the sphingomyelin-phosphodiesterase-acid-like-3b (SMPDL-3b) [35] confers efficiency in the treatment of focal segmental glomerulosclerosis (FSGS), including multi-drug-resistant forms [36]. The gene discussed is SMPDL3B; the disease is focal segmental glomerulosclerosis.