Other studies support the downregulation of HSPB2 in cancer, as well; specifically, HSPB2 mRNA was lower in esophageal squamous cell carcinoma cell lines, due to hypermethylation of the promoter of the HSPB2 gene [48], while HSPB2 mRNA was also found to be barely expressed in pancreatic cancer [49]. This evidence concerns the gene HSPB2 and esophageal squamous cell carcinoma.