Furthermore, although the role of HSPB2 has not been investigated so widely as the role of other HSPs, it was found to confer resistance to apoptosis in human BrCa cell lines, as it inhibited the apical caspase activation in the extrinsic apoptotic pathway [26], as well as to inhibit pancreatic cancer cell proliferation via activating targets of the TP53 signaling pathway, such as the RPRM, ADGRB1, and STEAP3 genes [49]. Here, HSPB2 is linked to familial pancreatic carcinoma.