The KEGG pathway analysis of 85 DEGs with reverse expression showed that microRNA in cancer was the only significantly different signaling pathway, including PTEN, CDC25A (cell division cycle 25A), SPRY2 (protein sprouty homolog 2), E2F2 (E2F2 transcription factor), PTGS2, and PLAU (urokinase-type plasminogen activator) (Figure 9). This evidence concerns the gene SPRY2 and cancer.