In this study, pBD2 showed anti-tumor potential by upregulating the expression of PTEN and downregulating the expression of SPRY2 and PLAU, and pBD2 was also shown to promote cell proliferation by upregulating the expression of CDC25A, E2F2, and PTGS2, which perhaps might lead to tumorigenesis. The gene discussed is SPRY2; the disease is neoplasm.