INS and type 2 diabetes mellitus: According to these findings, Inzucchi et al. revealed that insulin-stimulated peripheral glucose uptake increased by 13%, along with ~20% reduction in rates of HGP, resulting in a 58 mg/dL reduction in fasting plasma glucose concentration in patients with poorly controlled T2D after 3 months of metformin (1000 mg twice a day) treatment [42].