Both BDNF and GDNF are known for its neuroprotective effects in different pathologies of central and peripheral nervous systems, including hypoxic and ischemic damage [2,4,26], traumas, neurodegenerative diseases, Parkinson disease [27,28], and Alzheimer disease [29,30]. The gene discussed is GDNF; the disease is early-onset autosomal dominant Alzheimer disease.