Several lines of evidence support the role of HLA-G in COVID-19 pathogenesis, including (i) the increased levels of sHLA-G molecules in patients exhibiting various clinical manifestations of the disease [14,15,16,17,18], (ii) the increased number of immune system cells expressing HLA-G [16,19], (iii) the association of the HLA-G 3′untranslated region polymorphism with susceptibility to the disease [18], (iv) the increased tissue expression of HLA-G in case reports [20,21], and (v) the induction of the expression of hub genes, including HLA-G, in lung tissue infected by SARS-CoV-2 [22]. The gene discussed is HLA-G; the disease is COVID-19.