There are some molecular candidates for differential diagnosis between uterine LMS and leiomyoma, such as MED12, HMGA2, TOP2A, CHI3L1, MELK, PRC1, TOP2A, TPX2 DFF40, DFF45, the Bcl-2 gene, miRNAs (miR-1246 and miR-191-5p), STMN1, MKI67micro RNA and the let-7 family micro RNAs. This evidence concerns the gene MED12 and leiomyoma.