Our data revealed that in WT cells at early time points after infection, ACE2 localization is observed at the limiting membrane of cytoplasmic structures, such as tubules, ER vesicles and DMVs, suggesting that ACE2 expression rises in parallel with the increasing complexity of the cytoplasmic membrane remodeling that occurs following SARS-CoV-2 infection. The gene discussed is ACE2; the disease is infection.