As shown in Figure 1C–H, male sex (p = 0.0026), aggressive histological grade (p = 0.0003), lymph node metastasis (p = 0.0012), distant metastasis (p = 0.0225), advanced AJCC stage (p = 0.0016) and lymphovascular invasion (p = 0.0012) were significantly associated with high SHMT2 expression. Here, SHMT2 is linked to metastatic malignant neoplasm in the lymph nodes.