Discovered on gastrointestinal stromal tumor protein 1 (DOG1), also known as anoctamin-1/ANO1, is a calcium-activated chloride channel protein made up of eight transmembrane segments that was initially identified in gastrointestinal stromal tumors (GISTs) and is used as an immunohistochemical marker for these neoplasms [7]. The gene discussed is ANO1; the disease is gastrointestinal stromal tumor.