The positivity of DOG1, in fact, is essential to establish the acinar nature of a salivary neoplasm and may represent an ‘exaggerated acinar’ phenotype in ACC, different from neoplasms where DOG1 overexpression is due to gene amplification [29] and can be related to an increased tumor aggressiveness [9,10,11,13,14,16,17,18,19,20,21,22,23,24]. This evidence concerns the gene ANO1 and neoplasm.