CR1 and myeloid sarcoma: In MS, the genetic profile of inflammation genes could predict ocular manifestations; for instance, the C3 mutations were associated with ganglion cell/inner plexiform layer atrophy (p = 0.004) in the retina; meanwhile, C1QA and CR1 gene mutations were associated with low-contrast letter acuity (LCLA) loss, a hallmark ocular manifestation in MS.