KEGG pathway analysis indicated that the downregulated DEPs in the serum of NAFLD models mainly enriched in the complement and coagulation cascades, coronavirus disease COVID-19, systemic lupus erythematosus, Staphylococcus aureus infection, amoebiasis, JAK-STAT signaling pathway, and FoxO signaling pathway. The gene discussed is SOAT1; the disease is metabolic dysfunction-associated steatotic liver disease.