Mutations of the human Aldob gene could cause defective fructose metabolism and this disease is called hereditary fructose intolerance (HFI), patients with HFI could rapidly develop NAFLD and fibrosis with very low levels of fructose, and are prone to suffer from liver and kidney dysfunctions, especially among infants [47,48,49]. The gene discussed is ALDOB; the disease is metabolic dysfunction-associated steatotic liver disease.