NLRP3 and alcoholic liver diseases: Patients with alcoholic liver disease have increased serum levels of IL-1, TNF-α and IL-8, elevated expression of caspase-1 and nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3), neutrophilia, and activation of monocytes and macrophages in the liver [60].