CBR1 and malignant colon neoplasm: In previous studies, chrysin was reported to induce G2/M phase arrest in colon cancer cells [35], activate p38 and NK-κB/p65 in cervical cancer HeLa cells [36], induce apoptosis in MDA-MB-231 cells [26], enhance docetaxel-induced cytotoxicity in A549 cells [25], induce ROS-dependent autophagy through binding and inhibiting human carbonyl reductase 1, and improve the sensitivity of gemcitabine in PC cells [37].