COL4A2 and renal fibrosis: By contrast, consistent with the reduction in renal fibrosis in sFlt1-transfected mice (Figure 2C, p = 0.065), we found that luciferase expression measured 4 weeks after electroporation negatively correlated with whole-kidney mRNA expression of Col1a1, Col4a2 and Fn1 (Table 1), meaning that increased sFLT1 delivery correlates with reduced transcription of pro-fibrotic genes.