We have reproduced the finding that sFlt1 transfection has no deleterious effects on renal endothelial function in several independent models of kidney fibrosis; in the IRI model presented here, in a streptozotocin-induced DKD model [6] and in APOC1-tg mice [10] that develop glomerulosclerosis [21], transfection with sFlt1 did not drive renal damage or dysfunction. Here, APOC1 is linked to diabetic kidney disease.