In summary, our findings revealed the novel molecular pathway ADAR1/METTL3/ARHGAP5 connecting ADAR1, METTL3 and YTHDF1 (Figure 8), which may indicate ADAR1 or METTL3 as prognostic and therapeutical targets for the treatment of breast cancer. The gene discussed is METTL3; the disease is breast carcinoma.