SGK1, is a negative regulator of VEGF and BDNF, has been shown to interact with NF-KB, RAN, mTOR, FOXO3A, and is increased in a human hippocampal progenitor cell line during MDD, and decreased in the prefrontal cortex of PTSD patients [54,55,56]. The gene discussed is BDNF; the disease is major depressive disorder.