On the other hand, using the cytoHubba plugin in Cytoscape [53], a total of 10 nodes were identified as hub genes from the overall PPI network of TDP43-ALS motor neurons (TAF10, TAF1, TAF12, TAF6, TAF5, TAF11, TAF7, TAF4, AK6, and LSM7) (Figure 4B). This evidence concerns the gene AK6 and amyotrophic lateral sclerosis.