By this means, we identified RPL3, RPS24, MRPL28, TAF5, LSM7, MT-ND6, NDUFA13 and NDUFC1 as hub genes in SOD1- and TDP43-ALS patient-derived motor neurons, most of which were required for RNA metabolism and oxidative energy production. Here, TAF5 is linked to amyotrophic lateral sclerosis.