We studied iPSC-derived spinal motor neuron cultures from four different non related ALS patients (two of each carrying SOD1 and TDP43, respectively) which were compared to three different healthy control individuals (different families with different mutations; SOD1 D90A, SOD1 R115G, TDP43 S393L and TDP43 G294V, respectively; different controls from different families, for details see also Table 1). Here, TARDBP is linked to amyotrophic lateral sclerosis.