Upon analysis, peroxisome proliferator activated receptor gamma (PPARG), GATA-binding factor 2 (GATA2), and forkhead box C1 (FOXC1) were predicted as the most significant TFs in both SOD1- and TDP43-ALS showing their direct interactions with target genes associated with ribosome and transcription functions (Figure 4, Table 1). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.