Elevated plasma levels are associated with decline in neurogenesis and impaired learning and memory;  increases vascular permeability and activates p38-MAPK, Stat3 and NF-kappaB pathways in human coronary artery endothelial cells;  no significant differences in Eotaxin 1 plasma levels in healthy elderly and in people with preclinical AD. The gene discussed is CCL11; the disease is Alzheimer disease.