In the heart, a potential role of Eotaxin 1 in cardiovascular disease seems to be localized in the endothelial cells of coronary arteries by increasing vascular permeability and activating p38-MAPK, Stat3 and NF-kappaB pathways [89,90], but to the best of our knowledge, a direct connection between elevated Eotaxin 1 plasma levels and age-associated cardiovascular disease has not been shown so far. This evidence concerns the gene CCL11 and cardiovascular disorder.