Interestingly, in mouse 3T3-L1 adipocytes stimulated with lipopolysaccharides (LPS) that mimic inflammation occurring during obesity, the expression of both AQP3 and AQP7 is decreased through c-Jun N-terminal kinase (JNK)/NFkB signaling pathways and the AQP3 and AQP7 glycerol permeabilities are reduced probably concomitantly to protein internalization [101]. Here, AQP7 is linked to obesity due to melanocortin 4 receptor deficiency.