Moreover, APP increased AQP1 expression in brains from patients with Alzheimer’s disease through an epigenetic mechanism [57] and AQP1 overexpression reduced Aß production arising from APP cleavage by inhibiting the binding between ß-secretase (BACE1) and APP [58] (Figure 3B). This evidence concerns the gene AQP1 and early-onset autosomal dominant Alzheimer disease.