INS and obesity due to melanocortin 4 receptor deficiency: In their study, the authors further showed that ChREBP, a glucose-responsive transcription factor that regulates fatty acid synthesis and glycolysis [80], is highly regulated by GLUT4 in adipose tissue and is a key determinant of systemic insulin sensitivity and glucose homeostasis, indicating that adipose ChREBP may be a novel strategy for preventing and treating obesity-related metabolic dysfunction [70].