NLRP3 and myeloproliferative neoplasm: Y. Zhou et al. [14] showed that inflammasome-related genes (NLRP3, NF-κB1, CARD8, IL-1β, and IL-18) were highly expressed in patients with MPNs and that the NF-κB1 polymorphism (rs28362491) was more common in MPN patients than in the study group.