RIGI and neoplasm: Patients with the DDX58 rs10813831 G allele and DDX58 rs10738889 AA genotypes tended to have a higher percentage of tumor cells in the bone marrow than carriers of DDX58 rs10813831 AA and DDX58 rs10738889 G. The DDX58 gene encodes the intracellular receptor RIG-I, which is responsible for detecting foreign double-stranded RNA (dsRNA).