In the group of elderly patients, we showed statistically significant associations: TLR9 rs187084 C was more common among patients with favorable and intermediate risk according to ELN (p = 0.005); TLR4 rs4986791 T and TLR9 rs5743836 C were associated with lower CRP level at diagnosis of AML (p = 0.009 and p = 0.003, respectively). Here, TLR9 is linked to acute myeloid leukemia.