More recently, diverse approaches for detecting Ph-like ALL have been described, including the reduction of the genes that integrate GEPs combined with the screening of CRLF2/JAK and Abl type gene rearrangements, or the determination of the CRLF2 overexpression followed by the direct detection of the most frequent genomic abnormalities [12,18,19,20]. This evidence concerns the gene CRLF2 and acute lymphoblastic leukemia.