In contrast with ALL Hispanic children from Los Angeles [20], in the present study, the P2RY8::CRLF2 deletion was more frequent than the IGH::CRLF2 rearrangement; whereas, our IGH::CRLF2 frequency was close to the one reported by the mentioned group (9.6% vs. 12%, respectively), and it might be higher, considering that 21 patients with CRLF2 overexpression could not be included due to the lack of cell samples available for an additional FISH analysis. The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.