AKT1 and non-small cell lung carcinoma: PCGF3 was shown to promote proliferation and migration of non-small cell lung cancer (NSCLC) through the PI3K/Akt signaling pathway, while mutations in PCGF6 enhanced breast cancer cell migration and metastasis by upregulating the expression of epithelial-mesenchymal transition (EMT)-related genes [166,167].