We have planned for in-vivo follow-up studies in the mouse model of IBD (colitis) (using global and tissue-specific TRPA1 and TRPV1 knock out animals or TRPA1/V1 double knock out and, TRPA1/TRPV1 silencing approach in primary cells) to establish an exact role of neuronal nociceptive TRPA1 and TRPV1 channels in colonic mucosal alterations, especially in IBD conditions. This evidence concerns the gene TRPV1 and inflammatory bowel disease.