Emerging epidemiological, animal, and clinical studies show that consumption of curcumin can reduce the risk of some types of cancers [25,31,32], while a large body of evidence has unraveled the anticancer mechanisms of curcumin [2,31,33,34,35] including chemosensitisation of cancer cells to TRAIL’s proapoptotic action [16,17,36,37,38]. The gene discussed is TNFSF10; the disease is cancer.