PDK1 and cancer: Furthermore, PDK1 mediates chemoresistance in different cancer cell types by the activation of several oncogenic pathways, namely Polo-like kinase-1 (PLK1)- myelocytomatosis (MYC) Axis, Yes-associated Protein (YAP)/Hippo Pathway, and the serum and glucocorticoid inducible protein kinase (SGK) Axis [111].