In contrast with MSI1, MSI2 expression has been predominantly reported in hematological neoplasms, fundamentally in leukemia, probably due to the fact that MSI2 is mainly expressed in the hematopoietic system and is an important regulator of hematopoietic stem cells (HSCs) [111]. This evidence concerns the gene MSI2 and hematopoietic and lymphoid system neoplasm.